The endoplasmic reticulum (ER) is the key organelle for membrane biogenesis. Most lipids
are synthesized in the ER, and most membrane proteins are first inserted into the ER …

The number of described contact sites between different subcellular compartments and
structures in eukaryotic cells has increased dramatically in recent years and, as such, has …

Optical imaging beyond the diffraction limit has led to tremendous breakthroughs in recent
years. Compared with widely employed fluorescence-based approaches, label-free imaging …

Organelles do not act as autonomous discrete units but rather as interconnected hubs that
engage in extensive communication by forming close contacts called “membrane contact …

Biological membranes have a stunning ability to adapt their composition in response to
physiological stress and metabolic challenges. Little is known how such perturbations affect …

Lipid droplets (LDs) are fat storage organelles critical for energy and lipid metabolism. Upon
nutrient exhaustion, cells consume LDs via gradual lipolysis or via lipophagy, the en bloc …

Our body stores energy mostly in form of fatty acids (FAs) in lipid droplets (LDs). From there
the FAs can be mobilized and transferred to peroxisomes and mitochondria. This transfer is …

Over the past two decades, we have witnessed a growing appreciation for the importance of
membrane contact sites (CS) in facilitating direct communication between organelles. CS …

Organelles are membrane-lined structures that compartmentalize subcellular biochemical
functions. Therefore, interorganelle communication is crucial for cellular responses that …

Lipid droplets (LD) are organelles composed of a hydrophobic core (mostly triacylglycerol
and steryl esters) delineated by a lipid monolayer and found throughout the tree of life. LD …