Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a small
subfamily of proteins within the superfamily of pore-loop cation channels. In mammals, the …

Swynghedauw, Bernard. Molecular Mechanisms of Myocardial Remodeling. Physiol. Rev.
79: 215–262, 1999.—“Remodeling” implies changes that result in rearrangement of …

Pacemaking is a basic physiological process, and the cellular mechanisms involved in this
function have always attracted the keen attention of investigators. The “funny”(I f) current …

▪ Abstract Hyperpolarization-activated cation currents, termed If, Ih, or Iq, were initially
discovered in heart and nerve cells over 20 years ago. These currents contribute to a wide …

The aim of this review is to provide basic information on the electrophysiological changes
during acute ischemia and reperfusion from the level of ion channels up to the level of …

The generation of pacemaker activity in heart and brain is mediated by hyperpolarization-
activated cation channels that are directly regulated by cyclic nucleotides. We previously …

First described over a quarter of a century ago, the cardiac pacemaker “funny”(If) current has
been extensively characterized since, and its role in cardiac pacemaking has been …

About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …

It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …

After myocardial infarction (MI), the noninfarcted myocardium undergoes significant
hypertrophy as part of the post-MI structural remodeling. Electrophysiological changes …