[HTML][HTML] Oxidative stress and mitochondrial dysfunction in Alzheimer's disease
Alzheimer's disease (AD) exhibits extensive oxidative stress throughout the body, being
detected peripherally as well as associated with the vulnerable regions of the brain affected …
detected peripherally as well as associated with the vulnerable regions of the brain affected …
Oxidative stress in Alzheimer's disease
Z Chen, C Zhong - Neuroscience bulletin, 2014 - Springer
Oxidative stress plays a significant role in the pathogenesis of Alzheimer's disease (AD), a
devastating disease of the elderly. The brain is more vulnerable than other organs to …
devastating disease of the elderly. The brain is more vulnerable than other organs to …
Role of vitamin E as a lipid-soluble peroxyl radical scavenger: in vitro and in vivo evidence
E Niki - Free Radical Biology and Medicine, 2014 - Elsevier
Multiple reactive oxygen/nitrogen species induce oxidative stress. Mammals have evolved
with an elaborate defense network against oxidative stress, in which multiple antioxidant …
with an elaborate defense network against oxidative stress, in which multiple antioxidant …
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Brain aging is associated with diminished circadian clock output and decreased expression
of the core clock proteins, which regulate many aspects of cellular biochemistry and …
of the core clock proteins, which regulate many aspects of cellular biochemistry and …
[PDF][PDF] PUFAs: structures, metabolism and functions
A Wiktorowska-Owczarek, M Berezinska… - Adv Clin Exp …, 2015 - publicum.umed.lodz.pl
Polyunsaturated fatty acids (PUFAs) include two series of fatty acids: omega-6 and omega-3
series. PUFAs have amphiphatic properties: hydrophilic head and hydrophobic tail. Such …
series. PUFAs have amphiphatic properties: hydrophilic head and hydrophobic tail. Such …
Lipid peroxidation triggers neurodegeneration: a redox proteomics view into the Alzheimer disease brain
R Sultana, M Perluigi, DA Butterfield - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …
The isoprostanes—25 years later
Isoprostanes (IsoPs) are prostaglandin-like molecules generated independent of the
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …
cyclooxygenase (COX) by the free radical-induced peroxidation of arachidonic acid. The first …
Reactive oxygen species, cell signaling, and cell injury
K Hensley, KA Robinson, SP Gabbita… - Free Radical Biology …, 2000 - Elsevier
Oxidative stress has traditionally been viewed as a stochastic process of cell damage
resulting from aerobic metabolism, and antioxidants have been viewed simply as free …
resulting from aerobic metabolism, and antioxidants have been viewed simply as free …
Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid β-peptide
DA Butterfield, J Drake, C Pocernich… - Trends in molecular …, 2001 - cell.com
Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD)
patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is …
patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is …
Lipid peroxidation and protein oxidation in Alzheimer's disease brain: potential causes and consequences involving amyloid β-peptide-associated free radical …
DA Butterfield, CM Lauderback - Free Radical Biology and Medicine, 2002 - Elsevier
Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD)
patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is …
patients, and free radical oxidative stress, particularly of neuronal lipids and proteins, is …