Comprehensive review on Alzheimer's disease: causes and treatment
Z Breijyeh, R Karaman - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …
it is the main cause of dementia, which is characterized by a decline in thinking and …
Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders
Y Chen, J Xu, Y Chen - Nutrients, 2021 - mdpi.com
Emerging evidence indicates that gut microbiota is important in the regulation of brain
activity and cognitive functions. Microbes mediate communication among the metabolic …
activity and cognitive functions. Microbes mediate communication among the metabolic …
Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
A reduced removal of dysfunctional mitochondria is common to aging and age-related
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
neurodegenerative pathologies such as Alzheimer's disease (AD). Strategies for treating …
APOE in the bullseye of neurodegenerative diseases: Impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
New insights into atypical Alzheimer's disease in the era of biomarkers
Most patients with Alzheimer's disease present with amnestic problems; however, a
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …
substantial proportion, over-represented in young-onset cases, have atypical phenotypes …
Current and future treatments in Alzheimer disease: an update
KG Yiannopoulou… - Journal of central …, 2020 - journals.sagepub.com
Disease-modifying treatment strategies for Alzheimer disease (AD) are still under extensive
research. Nowadays, only symptomatic treatments exist for this disease, all trying to …
research. Nowadays, only symptomatic treatments exist for this disease, all trying to …
Recent advancements in pathogenesis, diagnostics and treatment of Alzheimer's disease
Background: The only conclusive way to diagnose Alzheimer's is to carry out brain autopsy
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
of the patient's brain tissue and ascertain whether the subject had Alzheimer's or any other …
Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia
E Connell, G Le Gall, MG Pontifex, S Sami… - Molecular …, 2022 - Springer
A consequence of our progressively ageing global population is the increasing prevalence
of worldwide age-related cognitive decline and dementia. In the absence of effective …
of worldwide age-related cognitive decline and dementia. In the absence of effective …
A fiber-deprived diet causes cognitive impairment and hippocampal microglia-mediated synaptic loss through the gut microbiota and metabolites
Background Cognitive impairment, an increasing mental health issue, is a core feature of the
aging brain and neurodegenerative diseases. Industrialized nations especially, have …
aging brain and neurodegenerative diseases. Industrialized nations especially, have …
Alzheimer's disease
JAS Lopez, HM González, GC Léger - Handbook of clinical neurology, 2019 - Elsevier
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and
functional decline associated with age together with a particular neuropathology. It was first …
functional decline associated with age together with a particular neuropathology. It was first …