The SLC4 family of bicarbonate (HCO3-) transporters
The SLC4 family consists of 10 genes (SLC4A1–5; SLC4A7–11). All encode integral
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
membrane proteins with very similar hydropathy plots—consistent with 10–14 …
Regulation of intracellular pH in eukaryotic cells.
IH Madshus - Biochemical journal, 1988 - ncbi.nlm.nih.gov
Vm= 1000 (R x TIF) ln [H+] O/[H+],) where R and F are the gas constant and Faraday
constant respectively, and Vm is membrane voltage in mV. At 22 C, Vm= 59 (pH,-pHO). At …
constant respectively, and Vm is membrane voltage in mV. At 22 C, Vm= 59 (pH,-pHO). At …
Acid pH in tumors and its potential for therapeutic exploitation
IF Tannock, D Rotin - Cancer research, 1989 - AACR
Measurement of pH in tissue has shown that the microenvironment in tumors is generally
more acidic than in normal tissues. Major mechanisms which lead to tumor acidity probably …
more acidic than in normal tissues. Major mechanisms which lead to tumor acidity probably …
Ionic basis of GABAA receptor channel function in the nervous system
K Kaila - Progress in neurobiology, 1994 - Elsevier
The concept of nervous inhibition as a physiological phenomenon in its own right--not
merely as a lack of excitation--was central to a number of early theories on the integrative …
merely as a lack of excitation--was central to a number of early theories on the integrative …
The divergence, actions, roles, and relatives of sodium-coupled bicarbonate transporters
MD Parker, WF Boron - Physiological reviews, 2013 - journals.physiology.org
The mammalian Slc4 (Solute carrier 4) family of transporters is a functionally diverse group
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
of 10 multi-spanning membrane proteins that includes three Cl-HCO3 exchangers (AE1–3) …
Regulation of intracellular pH
WF Boron - Advances in physiology education, 2004 - journals.physiology.org
The approach that most animal cells employ to regulate intracellular pH (pHi) is not too
different conceptually from the way a sophisticated system might regulate the temperature of …
different conceptually from the way a sophisticated system might regulate the temperature of …
The SLC4 family of HCO3 − transporters
MF Romero, CM Fulton, WF Boron - Pflügers Archiv, 2004 - Springer
The SLC4 family consists of ten genes. All appear to encode integral membrane proteins
with very similar hydropathy plots—consistent with the presence of 10–14 transmembrane …
with very similar hydropathy plots—consistent with the presence of 10–14 transmembrane …
Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2
I Medina, P Friedel, C Rivera, KT Kahle… - Frontiers in cellular …, 2014 - frontiersin.org
In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl−)-
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
permeable GABAA and glycine receptors (GABAAR and GlyR) depends on the intracellular …
Expression cloning and characterization of a renal electrogenic Na+ /HCO3− cotransporter
Bicarbonate transporters are the principal regulators of pH in animal cells, and play a vital
role in acid–base movement in the stomach, pancreas, intestine, kidney, reproductive …
role in acid–base movement in the stomach, pancreas, intestine, kidney, reproductive …
The regulation and modulation of pH in the nervous system
M Chesler - Progress in neurobiology, 1990 - Elsevier
The regulation of pH and its modulation by external stimuli have been studied in a wide
variety of animal cells (Roos and Boron, 1981; Busa and Nucitelli, 1984; Thomas, 1984; …
variety of animal cells (Roos and Boron, 1981; Busa and Nucitelli, 1984; Thomas, 1984; …