The cushioning function of large arteries encompasses distension during systole and recoil
during diastole which transforms pulsatile flow into a steady flow in the microcirculation …

BACKGROUND Each organ in the human body has its own capillary bed to carry out its
distinctive and versatile functions in response to dynamically changing systemic and local …

Organoids capable of forming tissue-like structures have transformed our ability to model
human development and disease. With the notable exception of the human heart, lineage …

Generation of thick vascularized tissues that fully match the patient still remains an unmet
challenge in cardiac tissue engineering. Here, a simple approach to 3D‐print thick …

The increasing prevalence of diabetes has resulted in a global epidemic. Diabetes is a
major cause of blindness, kidney failure, heart attacks, stroke and amputation of lower limbs …

Human cortical organoids (hCOs), derived from human embryonic stem cells (hESCs),
provide a platform to study human brain development and diseases in complex three …

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition
known as cerebral amyloid angiopathy (CAA), which impairs blood–brain barrier (BBB) …

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease
modeling and have unlocked new possibilities for understanding the mechanisms governing …

Genome-wide association studies (GWASs) implicate the PHACTR1 locus (6p24) in risk for
five vascular diseases, including coronary artery disease, migraine headache, cervical …

Organoid technology provides a revolutionary paradigm toward therapy but has yet to be
applied in humans, mainly because of reproducibility and scalability challenges. Here, we …