Cell surface transmembrane receptors often form nanometer-to micrometer-scale clusters to
initiate signal transduction in response to environmental cues. Extracellular ligand …

Inhibition of vascular endothelial growth factor A (VEGFA)/vascular endothelial growth factor
receptor 2 (VEGFR2) signaling is a common therapeutic strategy in oncology, with new …

Background Minimal change disease and primary focal segmental glomerulosclerosis in
adults, along with idiopathic nephrotic syndrome in children, are immune-mediated …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Genetic studies of hereditary forms of nephrotic syndrome have identified several proteins
that are involved in regulating the permselective properties of the glomerular filtration …

Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic
syndrome, resulting from impaired slit diaphragm (SD) formation in glomerular podocytes …

Podocytes are a major component of the glomerular blood filtration barrier, and alterations to
the morphology of their unique actin-based foot processes (FP) are a common feature of …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …

The podocyte is a key component of the glomerular filtration barrier. Podocyte dysfunction is
central to the underlying pathophysiology of many common glomerular diseases, including …

Proteinuric kidney diseases are a group of disorders with diverse pathological mechanisms
associated with significant losses of protein in the urine. The glomerular filtration barrier …