The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Regulation of intracellular calcium is a critical component of cardiac electrophysiology and
excitation-contraction coupling. The calcium spark, the fundamental element of the …

One of the major challenges in modern biology is to understand how the molecular
components of a living cell operate in a highly noisy environment. What are the specific …

Written for practitioners in the field, this critically acclaimed bestseller provides authoritative
information focused on the investigation of drug-related deaths and practical approaches to …

The interactions between mathematics and physiology have a long and illustrious history, of
which the study of calcium signalling is but a small chapter. Nevertheless, for those involved …

This is a book on mathematical neuroscience, in which the unifying theme is wavelike
phenomena at multiple spatial and temporal scales. There are already several excellent …

We present what we believe to be a new mathematical model of Ca 2+ leak from the
sarcoplasmic reticulum (SR) in the heart. To our knowledge, it is the first to incorporate a …

Abstract Cardiac Ca 2+-induced Ca 2+ release (CICR) occurs by a regenerative activation of
ryanodine receptors (RyRs) within each Ca 2+-releasing unit, triggered by the activation of L …

The heart is an organ with high-energy demands in which the mitochondria are most
abundant. They are considered the powerhouse of the cell and occupy a central role in …

In this chapter, neural field theory is used to model binocular rivalry waves. During binocular
rivalry, visual perception switches back and forth between different images presented to the …