The σ 1 and σ 2 receptors are enigmatic proteins that have attracted attention for decades
due to the chemical diversity and therapeutic potential of their ligands. However, despite …

The Sigma 1 receptor (Sigmar1) is a ubiquitously expressed multifunctional inter-organelle
signaling chaperone protein playing a diverse role in cellular survival. Recessive mutation in …

Although ionotropic glutamate receptors and nicotinic receptors for acetylcholine (ACh) have
usually been studied separately, they are often co-localized and functionally inter …

The discovery of a highly selective putative sigma-1 (σ1) receptor agonist, PRE-084, has
revealed the numerous potential uses of this receptor subtype as a therapeutic target. While …

L‐type voltage‐gated calcium ion channels (L‐VGCCs) have been demonstrated to be the
mediator of several significant intracellular activities in excitable cells, such as neurons …

Abstract Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and
psychiatric disorders and are a novel target for the treatment of such disorders. Sig-1R …

The sigma-1 receptor (Sig-1R) has emerged as a significant target in the realm of pain
management and has been the subject of extensive research. Nonetheless, its specific …

Both bioactive sphingolipids and Sigma-1 receptor (S1R) chaperones occur ubiquitously in
mammalian cell membranes. Endogenous compounds that regulate the S1R are important …

ABSTRACT The World Health Organization (WHO) has not declared the COVID-19
pandemic over, a disease now associated with approximately 226 million cases with over …

Abstract The sigma-1 receptor (σ1) is a single 25 kD polypeptide that acts as a chaperone
protein residing primarily in the endoplasmic reticulum Its interaction with mitochondria at …