Leptomeningeal metastasis (LM), ie the seeding of tumor cells to the cerebrospinal fluid
(CSF) and the leptomeninges, is a devastating and mostly late-stage complication of various …

Leptomeningeal metastasis occurs in~ 5% of all patients with cancer and is the third most
common metastatic complication of the central nervous system. Staging of leptomeningeal …

PURPOSE Photon involved-field radiotherapy (IFRT) is the standard-of-care radiotherapy for
patients with leptomeningeal metastasis (LM) from solid tumors. We tested whether proton …

Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the
leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung …

Background Leptomeningeal metastases (LM) are associated with limited survival and
treatment options. While involved-field radiotherapy is effective for local palliation, it lacks …

Neoplastic meningitis is a complication of the CNS that occurs in 3–5% of patients with
cancer and is characterised by multifocal neurological signs and symptoms. Diagnosis is …

Temozolomide-based chemotherapy represents an incremental improvement in the
treatment of patients with high-grade gliomas. Notwithstanding a survival benefit in a subset …

Background: Gliomas are the most common type of primary brain tumor. Nearly two-thirds of
gliomas are highly malignant lesions that account for a disproportionate share of brain tumor …

The prognosis of leptomeningeal metastasis (LM) from solid tumors is extremely poor,
especially for patients with adverse prognostic factors. In this phase II clinical trial, we …

The surgical management of recurrent glioblastoma multiforme is controversial. Recent
publications suggest that re-operation provides 3–5 months median survival, without …