Obesity has become a global epidemic that has a negative impact on population health and
the economy of nations. Genetic predispositions have been demonstrated to have a …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

Nutritional factors play a life-long role in human health. Indeed, there is growing evidence
that one of the mechanisms by which nutrients and bioactive compounds affect metabolic …

Cardiovascular diseases (CVDs) are the major causes of death in the western world. The
incidence of cardiovascular disease as well as the rate of cardiovascular mortality and …

Recent studies have implicated resveratrol and pterostilbene, a resveratrol derivative, in the
protection against age-related diseases including Alzheimer's disease (AD). However, the …

Abstract Sirtuin 1 (SIRT1), the mammalian ortholog of yeast Sir2, is a highly conserved
NAD+-dependent protein deacetylase that has emerged as a key metabolic sensor that …

Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-
ribosyltransferases that can extend the lifespan of several lower model organisms including …

Life expectancy has grown dramatically in modern times. This increase, however, is not
accompanied by the same increase in healthspan. Efforts to extend healthspan through …

Improvements in health care have increased human life expectancy in recent decades, and
the elderly population is thus increasing in most developed countries. Unfortunately this still …

The cellular NAD+/NADH level controls Sir2 (silent information regulator 2) deacetylase
activity in regulating aging in lower species. Much work has been put forth to identify ways to …