Aortic valve stenosis secondary to aortic valve calcification is the most common valve
disease in the Western world. Calcification is a result of pathological proliferation and …

Background and aims Inflammation is initiates the propagation phase of aortic valve
calcification. The activation of NLRP3 signaling in macrophages plays a crucial role in the …

Background Calcific aortic stenosis (CAS) is more prevalent, occurs earlier, progresses
faster and has worse outcomes in patients with chronic kidney disease (CKD). The uremic …

Ectopic mineralization refers to the deposition of mineralized complexes in the extracellular
matrix of soft tissues. Calcific aortic valve disease, vascular calcification, gallstones, kidney …

Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by
extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation …

Ethnopharmacological relevance Long-term chronic inflammation often leads to chronic
diseases. Although Sophora flavescens has been shown to have anti-inflammatory …

Este presente estudio se centra en la enfermedad valvular aórtica calcificada y explora el
papel de la glutamina y la glutaminolisis en la calcificación e inflamación de las células …

Kenntnisse über die molekularen pathogenetischen Mechanismen bilden die Grundlage
neuer zielspezifischer Therapien und können wichtige Hinweise auf Wirkungen und …

Introduction and objectives: Inflammation has been linked to metabolic reprogramming in
several diseases, including cardiovascular pathogenesis. Calcific aortic valve disease …

Valvular heart disease (VHD) includes stenosis and regurgitation of the mitral and aortic
valves (AV). The prevalence of moderate to severe VHD is~ 2.5% in the general population …