Tactile sensory information from facial whiskers provides nocturnal tunnel-dwelling rodents,
including mice and rats, with important spatial and textural information about their immediate …

A widely discussed hypothesis in neuroscience is that transiently active ensembles of
neurons, known as" cell assemblies," underlie numerous operations of the brain, from …

We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …

We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of
juvenile rat. The reconstruction uses cellular and synaptic organizing principles to …

The strength of synaptic connections fundamentally determines how neurons influence each
other's firing. Excitatory connection amplitudes between pairs of cortical neurons vary over …

The selectivity of neuronal responses arises from the architecture of excitatory and inhibitory
connections. In the primary visual cortex, the selectivity of a neuron in layer 2/3 for stimulus …

In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory
neurons, defined by the organization of their synaptic connections. Although connections …

Cortical processing reflects the interplay of synaptic excitation and synaptic inhibition.
Rapidly accumulating evidence is highlighting the crucial role of inhibition in shaping …

Many theories of brain function propose that activity in sparse subsets of neurons underlies
perception and action. To place a lower bound on the amount of neural activity that can be …

One goal of researchers in neuroscience, psychology, and artificial intelligence is to build
theoretical models that are able to explain the flexibility and adaptiveness of biological …