Children born small for gestational age (SGA), defined as a birth weight and/or length
below− 2 SD score (SDS), comprise a heterogeneous group. The causes of SGA are …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

The generation of neurons in the adult mammalian brain requires the activation of quiescent
neural stem cells (NSCs). This activation and the sequential steps of neuron formation from …

Abstract This International Consensus Guideline was developed by experts in the field of
small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus …

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …

Rather than being a passive, haphazard process of wear and tear, lifespan can be
modulated actively by components of the insulin/insulin-like growth factor I (IGFI) pathway in …

Depending on the definitions used, up to 10% of all live-born neonates are small for
gestational age (SGA). Although the vast majority of these children show catch-up growth by …

IGF-I is expressed in virtually every tissue of the body, but with much higher expression in
the liver than in any other tissue. Studies using mice with liver-specific IGF-I knockout have …

Growth hormone deficiency (GHD) is a clinical syndrome that can manifest either as isolated
or associated with additional pituitary hormone deficiencies. Although diminished height …