Inflammation in epileptogenesis after traumatic brain injury

KM Webster, M Sun, P Crack, TJ O'Brien… - Journal of …, 2017 - Springer
Background Epilepsy is a common and debilitating consequence of traumatic brain injury
(TBI). Seizures contribute to progressive neurodegeneration and poor functional and …

Neuroinflammatory mediators in acquired epilepsy: an update

Y Chen, MM Nagib, N Yasmen, MN Sluter… - Inflammation …, 2023 - Springer
Epilepsy is a group of chronic neurological disorders that have diverse etiologies but are
commonly characterized by spontaneous seizures and behavioral comorbidities. Although …

Anti-inflammatory small molecules to treat seizures and epilepsy: from bench to bedside

A Dey, X Kang, J Qiu, Y Du, J Jiang - Trends in pharmacological sciences, 2016 - cell.com
As a crucial component of brain innate immunity, neuroinflammation initially contributes to
neuronal tissue repair and maintenance. However, chronic inflammatory processes within …

[HTML][HTML] Cytokines and epilepsy

G Li, S Bauer, M Nowak, B Norwood, B Tackenberg… - Seizure, 2011 - Elsevier
Epilepsy is a common chronic neurological disorder affecting approximately 8 out of 1000
people. Its pathophysiology, however, has remained elusive in many regards …

Inflammation and prevention of epileptogenesis

T Ravizza, S Balosso, A Vezzani - Neuroscience letters, 2011 - Elsevier
CNS injuries such as trauma, stroke, viral infection, febrile seizures, status epilepticus
occurring either in infancy or during a lifetime are considered common risk factors for …

Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy

NP Turrin, S Rivest - Neurobiology of disease, 2004 - Elsevier
In the present study, the expression of pro-inflammatory transcripts was assessed across the
brain of mice having undertaken pilocarpine-induced seizures. Pilocarpine-induced marked …

[HTML][HTML] Inflammatory and immune mechanisms underlying epileptogenesis and epilepsy: From pathogenesis to treatment target

I Mukhtar - Seizure, 2020 - Elsevier
Epilepsy is a brain disease associated with epileptic seizures as well as with
neurobehavioral outcomes of this condition. In the last century, inflammation emerged as a …

Expressions of tumor necrosis factor alpha and microRNA-155 in immature rat model of status epilepticus and children with mesial temporal lobe epilepsy

MU Ashhab, A Omran, H Kong, N Gan, F He… - Journal of Molecular …, 2013 - Springer
Recently, the role of inflammation has attracted great attention in the pathogenesis of mesial
temporal lobe epilepsy (MTLE), and microRNAs start to emerge as promising new players in …

Intranasal administration of human IL-6 increases the severity of chemically induced seizures in rats

AV Kalueff, KA Lehtimaki, A Ylinen, J Honkaniemi… - Neuroscience …, 2004 - Elsevier
Here we study the role of a pleiotropic pro-inflammatory cytokine, interleukin-6 (IL-6), in
epilepsy. To examine this problem, we used human recombinant IL-6 applied intranasally …

Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword

SD Croll, JH Goodman, HE Scharfman - Recent advances in epilepsy …, 2004 - Springer
Vascular endothelial growth factor (VEGF) is a vascular growth factor which induces
angiogenesis (the development of new blood vessels), vascular permeability, and …