Neisseria gonorrhoeae is the second most common bacterial sexually transmitted infection
in the world after Chlamydia trachomatis. The pathogen has developed resistance to every …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a recently emerged virus
that causes coronavirus infectious disease 2019 (COVID-19). SARS-CoV-2 spike protein …

Background: Sexually transmitted gonorrhea, caused by the Gram-negative diplococcus
Neisseria gonorrhoeae, continues to be a serious global health challenge despite efforts to …

Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but
cholesterol alone is insufficient to explain their cell and host tropism. Here, we show that all …

Mycobacterium abscessus is an emerging and difficult-to-manage mycobacterial species
that exhibits smooth (S) or rough (R) morphotypes. Disruption of glycopeptidolipid (GPL) …

Plasmodium falciparum is a human-adapted apicomplexan parasite that causes the most
dangerous form of malaria. P. falciparum cysteine-rich protective antigen (PfCyRPA) is an …

ABSTRACT Multidrug-resistant (MDR) N. gonorrhoeae is a current public health threat. New
therapies are urgently needed. PBT2 is an ionophore that disrupts metal homeostasis. PBT2 …

Objectives Ceftriaxone therapy for gonorrhoea has become under increasing pressure due
to waning susceptibility levels and emergence of high-level resistant strains such as the …

While antimicrobial resistance (AMR) is seen in both Neisseria gonorrhoeae and Neisseria
meningitidis, the former has become resistant to commonly available over-the-counter …

Gonorrhea remains a major global public health problem because of the high incidence of
infection (estimated 82 million cases in 2020) and the emergence and spread of Neisseria …