Sepsis, a life-threatening organ dysfunction, results from a dysregulated host response to
invading pathogens that may be characterized by overwhelming systemic inflammation or …

Originally described as the renal aldosterone receptor that regulates sodium homeostasis, it
is now clear that mineralocorticoid receptors (MRs) are widely expressed, including in …

Background Septic shock is characterized by dysregulation of the host response to infection,
with circulatory, cellular, and metabolic abnormalities. We hypothesized that therapy with …

Sepsis is one of the most frequent causes of death among patients in intensive care units.
Many therapeutic strategies have been assessed without the desired success rates. A key …

In critical illness, homeostatic corrections representing the culmination of hundreds of
millions of years of evolution, are modulated by the activated glucocorticoid receptor alpha …

Sepsis has remained a high mortality rate worldwide. Endothelial cell dysfunction is closely
associated with the development of sepsis. Hydrocortisone has potent immunological and …

Background The combination of intravenous hydrocortisone and enteral fludrocortisone may
reduce mortality in patients with septic shock. The optimal dose and reliability of absorption …

Purpose To determine if adrenocortical gene expression is associated with clinical
outcomes or response to corticosteroid treatment in septic shock. Methods A pre-specified …

In the retina, the mineralocorticoid receptor is expressed in retinal and choroidal vessels and
in cells from neural and glial origins. Like in the brain, the major ligand of the …

The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function
is not clear. Here, we analyze the role of ENaC in the regulation of endothelium-dependent …