The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …

Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …

Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …

Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …

Postprandial glucose, together with related hyperinsulinemia and lipidaemia, has been
implicated in the development of chronic metabolic diseases like obesity, type 2 diabetes …

In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle”
to describe fuel flux between and fuel selection by tissues. The original biochemical …

Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …

Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …

Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …

BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …