Dietary carbohydrates and fats in nonalcoholic fatty liver disease
H Yki-Järvinen, PK Luukkonen, L Hodson… - Nature reviews …, 2021 - nature.com
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has dramatically
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
increased in parallel with the epidemic of obesity. Controversy has emerged around dietary …
Emerging roles of vascular endothelium in metabolic homeostasis
X Pi, L Xie, C Patterson - Circulation Research, 2018 - Am Heart Assoc
Our understanding of the role of the vascular endothelium has evolved over the past 2
decades, with the recognition that it is a dynamically regulated organ and that it plays a …
decades, with the recognition that it is a dynamically regulated organ and that it plays a …
[HTML][HTML] AdipoAtlas: A reference lipidome for human white adipose tissue
Obesity, characterized by expansion and metabolic dysregulation of white adipose tissue
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …
(WAT), has reached pandemic proportions and acts as a primer for a wide range of …
Gluteofemoral body fat as a determinant of metabolic health
Body fat distribution is an important metabolic and cardiovascular risk factor, because the
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …
proportion of abdominal to gluteofemoral body fat correlates with obesity-associated …
Impact of postprandial glycaemia on health and prevention of disease
EE Blaak, JM Antoine, D Benton, I Björck… - Obesity …, 2012 - Wiley Online Library
Postprandial glucose, together with related hyperinsulinemia and lipidaemia, has been
implicated in the development of chronic metabolic diseases like obesity, type 2 diabetes …
implicated in the development of chronic metabolic diseases like obesity, type 2 diabetes …
The Randle cycle revisited: a new head for an old hat
L Hue, H Taegtmeyer - American Journal of Physiology …, 2009 - journals.physiology.org
In 1963, Lancet published a paper by Randle et al. that proposed a “glucose-fatty acid cycle”
to describe fuel flux between and fuel selection by tissues. The original biochemical …
to describe fuel flux between and fuel selection by tissues. The original biochemical …
Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes
H Li, J Ren, Y Li, Q Wu, J Wei - Frontiers in Endocrinology, 2023 - frontiersin.org
Obesity has been associated with oxidative stress. Obese patients are at increased risk for
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …
diabetic cognitive dysfunction, indicating a pathological link between obesity, oxidative …
[HTML][HTML] Targeting fatty acid and carbohydrate oxidation—a novel therapeutic intervention in the ischemic and failing heart
Cardiac ischemia and its consequences including heart failure, which itself has emerged as
the leading cause of morbidity and mortality in developed countries are accompanied by …
the leading cause of morbidity and mortality in developed countries are accompanied by …
Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice
M Schweiger, M Romauch, R Schreiber… - Nature …, 2017 - nature.com
Elevated circulating fatty acids (FAs) contribute to the development of obesity-associated
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …
metabolic complications such as insulin resistance (IR) and non-alcoholic fatty liver disease …
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro
C Pirazzi, M Adiels, MA Burza, RM Mancina… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: The robust association between non-alcoholic fatty liver disease
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …
(NAFLD) and the genetic variant I148M (rs738409) in PNPLA3 has been widely replicated …