The three sets of symptoms associated with schizophrenia—positive, negative, and
cognitive—are burdensome and have serious effects on public health, which affects up to …

Alzheimer's Disease (AD) is a currently incurable but increasingly prevalent fatal and
progressive neurodegenerative disease, demanding consideration of therapeutically …

Recent findings link cognitive impairment and inflammatory-immune dysregulation in
schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, heterogeneity and …

Schizophrenia (SCZ) is a complex, heritable and polygenic neuropsychiatric disease, which
disables the patients as well as decreases their life expectancy and quality of life. Common …

We compared transcriptomic profiles of cerebral organoids differentiated from induced
pluripotent stem cells of eight schizophrenia and eight bipolar disorder patients to identify …

Our understanding of lysosomes has undergone a significant transformation in recent years,
from the view that they are static organelles primarily responsible for the disposal and …

With recent advancements in psychiatric genomics, as a field,“stem cell-based disease
modelers” were given the exciting yet daunting task of translating the extensive list of …

Induced pluripotent stem cell (iPSC) technology is more and more used for the study of
genetically complex human disease but is challenged by variability, sample size and …

Schizophrenia (SCZ) is a chronic, highly relapsing, severe mental disorder with an unclear
etiology. Cytokine-mediated neuroimmune abnormalities have been repeatedly revealed. IL …

MicroRNAs have pivotal roles in gene regulation. However, microRNAs that have causal
effects on schizophrenia remain largely unknown. To investigate the causal relationships …