Mouse models have become an indispensable tool in translational research of human
airway disease and have provided much of our understanding of the pathogenesis of airway …

Background Unrestrained plethysmography has been used to monitor bronchoconstriction
because of its ease of use and ability to measure airway responsiveness in conscious …

Small-animal physiology studies are typically complicated, but the level of complexity is
greatly increased when performing live-animal X-ray imaging studies at synchrotron and …

Prions, the agents causing transmissible spongiform encephalopathies, colonize the brain of
hosts after oral, parenteral, intralingual, or even transdermal uptake. However, prions are not …

Presbyphagia affects approximately 40% of otherwise healthy people over 60 years of age.
Hence, it is a condition of primary aging rather than a consequence of primary disease. This …

Pediatric obstructive sleep apnea (OSA), a relatively common sleep-related breathing
disorder affecting∼ 1-5% of children, is often caused by anatomical obstruction and/or …

Given the ubiquitous use of mice to study lung disease, it is curious that more investigators
do not use repeated intubation to study mechanical and cellular changes in individual mice …

Air volume changes created by a conscious subject breathing spontaneously within a body
box are at the basis of plethysmography, a technique used to non-invasively assess some …

Nicotine is an addictive drug whose popularity has recently increased, particularly among
adolescents, because of the availability of electronic nicotine devices (ie,“vaping”) and …

Abstract Background and Objective Although the mouse is a widely used animal model in
biomedical research, there are only a few published studies on its nasal aerodynamics …