Transcriptional regulation of catabolic pathways is a central mechanism by which cells
respond to physiological cues to generate the energy required for anabolic pathways …

Although low risk localised prostate cancer has an excellent prognosis owing to effective
treatments, such as surgery, radiation, cryosurgery and hormone therapy, metastatic …

Anabolic metabolism mediated by aberrant growth factor signalling fuels tumour growth and
progression. The first biochemical descriptions of the altered metabolic nature of solid …

Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer
malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to …

Phosphatidylinositol (PI) regulating enzymes are frequently altered in cancer and have
become a focus for drug development. Here, we explore the phosphatidylinositol-5 …

Androgen receptor (AR) signaling reprograms cellular metabolism to support prostate
cancer (PCa) growth and survival. Another key regulator of cellular metabolism is mTOR, a …

Metabolic reprogramming is associated with re/activation and antagonism of androgen
receptor (AR) signaling that drives prostate cancer (PCa) progression to castration …

Background The development of castration-resistant prostate cancer (CRPC) remains a
major obstacle in the treatment of prostate cancer (PCa). Dysregulated mitochondrial …

Because of their historical mode of action, endocrine-disrupting chemicals (EDCs) are
associated with sex-steroid receptors, namely the two estrogen receptors (ERα and ERβ) …

Metabolic reprogramming has been recognised as a hallmark in solid tumours. Malignant
modification of the tumour's bioenergetics provides energy for tumour growth and …