Cancer genomes have been explored from the early 2000s through massive exome
sequencing efforts, leading to the publication of The Cancer Genome Atlas in 2013 …

Since the first half of the twentieth century, evolutionary theory has been dominated by the
idea that mutations occur randomly with respect to their consequences. Here we test this …

Abstract Changes in gene expression are involved in many brain functions. Epigenetic
processes modulate gene expression by histone modification and DNA methylation or RNA …

Background Multiple myeloma (MM) is a heterogeneous disease with different patterns of
clonal evolution and a complex tumor microenvironment, representing a challenge for …

Relating genetic variants to behavior remains a fundamental challenge. To assess the utility
of DNA methylation marks in discovering causative variants, we examined their relationship …

Mutation rate is a fundamental parameter in population genetics. Apart from being an
important scaling parameter for demographic and phylogenetic inference, it allows one to …

Background: Recently, increasing evidence has implicated methylenetetrahydrofolate
reductase (MTHFR) gene mutation as a risk factor for ischemic stroke (IS) in the general …

Methylation microarray and bisulphite sequencing are often used to study 5'-methylcytosine
(5'-mC) modification of CpG dinucleotides in the human genome. Although both …

Classical evolutionary theory maintains that mutation rate variation between genes should
be random with respect to fitness–and evolutionary optimization of genic mutation rates …

ABSTRACT TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning
with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains …