Melanocyte development provides an excellent model for studying more complex
developmental processes. Melanocytes have an apparently simple aetiology, differentiating …

Fascin actin-bundling protein 1 (FSCN1) is a highly conserved actin-bundling protein that
cross links F-actin microfilaments into tight, parallel bundles. Elevated FSCN1 levels have …

Melanocytes, which originate from the neuroectoderm, are specialized cells responsible for
producing pigments and possessing a dendritic morphology. These cells migrate to the …

Simple Summary Cell migration is an essential biological process that regulates both
development and diseases, such as cancer metastasis. Therefore, understanding the factors …

Abstract Myosin-X (Myo10) is an unconventional myosin best known for its striking
localization to the tips of filopodia. Despite the broad expression of Myo10 in vertebrate …

Lineage dedifferentiation toward a mesenchymal‐like state displaying myofibroblast and
fibrotic features is a common mechanism of adaptive and acquired resistance to targeted …

The individual molecular pathways downstream of Cdc42, Rac, and Rho GTPases are well
documented, but we know surprisingly little about how these pathways are coordinated …

Directional migration of neural crest (NC) cells is essential for patterning the vertebrate
embryo, including the craniofacial skeleton. Extensive filopodial protrusions in NC cells are …

Previous cell biological studies demonstrate that the actin bundling protein fascin1 regulates
cell motility, migration and invasion. Human studies demonstrate that fascin1 is upregulated …

Actin cytoskeleton is crucial to support spermatogenesis in the mammalian testis. However,
the molecular mechanism (s) underlying changes of actin cytoskeletal organization in …