Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Cancer is characterized by uncontrolled tumour cell proliferation resulting from aberrant
activity of various cell cycle proteins. Therefore, cell cycle regulators are considered …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Hematologic malignancies are one of the most common cancers, and the incidence has
been rising in recent decades. The clinical and molecular features of hematologic …

Purpose Aurora A kinase (AAK) is overexpressed in aggressive lymphomas and can
correlate with more histologically aggressive forms of disease. We therefore designed a …

Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic
drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs …

Aurora kinases control multiple events during cell cycle progression and are essential for
mitotic and meiotic bipolar spindle assembly and function. There are three Aurora kinases in …

Abstract Purpose: Aurora A kinase (AAK) is a key regulator of mitosis and a target for
anticancer drug development. This phase I study investigated the safety, pharmacokinetics …

Gastrointestinal (GI) cancers are a major cause of cancer-related deaths. During the last two
decades, several studies have shown amplification and overexpression of Aurora kinase A …

Alisertib (ALS) is an investigational potent Aurora A kinase inhibitor currently undergoing
clinical trials for the treatment of hematological and non-hematological malignancies …