Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy

RJ Griffin, MM Ahmed, B Amendola, O Belyakov… - International Journal of …, 2020 - Elsevier
The National Cancer Institute's Radiation Research Program, in collaboration with the
Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High …

Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue

E Bräuer-Krisch, R Serduc, EA Siegbahn… - … Research/Reviews in …, 2010 - Elsevier
Microbeam radiation therapy (MRT) uses highly collimated, quasi-parallel arrays of X-ray
microbeams of 50–600keV, produced by third generation synchrotron sources, such as the …

Interlaced x-ray microplanar beams: a radiosurgery approach with clinical potential

FA Dilmanian, Z Zhong, T Bacarian… - Proceedings of the …, 2006 - National Acad Sciences
Studies have shown that x-rays delivered as arrays of parallel microplanar beams
(microbeams), 25-to 90-μm thick and spaced 100–300 μm on-center, respectively, spare …

Proton‐minibeam radiation therapy: a proof of concept

Y Prezado, GR Fois - Medical physics, 2013 - Wiley Online Library
Purpose: This Monte Carlo simulation work aims at studying a new radiotherapy approach
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …

Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues

JC Crosbie, RL Anderson, K Rothkamm… - International Journal of …, 2010 - Elsevier
PURPOSE: High-dose synchrotron microbeam radiation therapy (MRT) can be effective at
destroying tumors in animal models while causing very little damage to normal tissues. The …

FLASH and minibeams in radiation therapy: the effect of microstructures on time and space and their potential application to protontherapy

A Mazal, Y Prezado, C Ares, L de Marzi… - The British Journal of …, 2020 - academic.oup.com
After years of lethargy, studies on two non-conventional microstructures in time and space of
the beams used in radiation therapy are enjoying a huge revival. The first effect called …

[HTML][HTML] Effects of microbeam radiation therapy on normal and tumoral blood vessels

A Bouchet, R Serduc, JA Laissue, V Djonov - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …

Prospects for microbeam radiation therapy of brain tumours in children to reduce neurological sequelae

JA Laissue, H Blattmann, HP Wagner… - … Medicine & Child …, 2007 - Wiley Online Library
Microbeam radiation therapy (MRT), a form of experimental radiosurgery of tumours using
multiple parallel, planar, micrometres‐wide, synchrotron‐generated X‐ray beams …

Tolerance to dose escalation in minibeam radiation therapy applied to normal rat brain: long-term clinical, radiological and histopathological analysis

Y Prezado, P Deman, P Varlet, G Jouvion… - Radiation …, 2015 - meridian.allenpress.com
The major limitation to reaching a curative radiation dose in radioresistant tumors such as
malignant gliomas is the high sensitivity to radiation and subsequent damage of the …

[HTML][HTML] Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?

FA Dilmanian, Y Qu, LE Feinendegen, LA Peña… - Experimental …, 2007 - Elsevier
OBJECTIVE: Normal tissues, including the central nervous system, tolerate single exposures
to narrow planes of synchrotron-generated x-rays (microplanar beams; microbeams) up to …