A variety of acute brain insults can induce epileptogenesis, a complex process that results in
acquired epilepsy. Despite advances in understanding mechanisms of epileptogenesis …

In the last 30 years, over 20 new anti-seizure medicines (ASMs) have been introduced into
the market for the treatment of epilepsy using well-established preclinical seizure and …

It is well established that epilepsy is associated with numerous neurobehavioral
comorbidities, with a bidirectional relationship; people with epilepsy have an increased …

KCNMA1 forms the pore of BK K+ channels, which regulate neuronal and muscle
excitability. Recently, genetic screening identified heterozygous KCNMA1 variants in a …

Various etiological factors, such as head injury, chemical intoxication, tumors, and gene
mutation, can induce epileptogenesis. In animal models, status epilepticus (SE) triggers …

Objective Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for
epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to …

The aim of epilepsy models is to investigate disease ontogenesis and therapeutic
interventions in a consistent and prospective manner. The kainic acid-induced status …

Many disease‐relevant phenotypes modeled in inbred mice have been shown to be strain‐
dependent, indicating the important influence of genetic background on disease …

Here we describe a novel mouse model of temporal lobe epilepsy (TLE) that moves the site
of kainate injection from the rodent dorsal hippocampus (corresponding to the human …

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related
mortality, but the precise cellular substrates involved remain elusive. Epilepsy-associated …