The phospholipase A2 (PLA2) superfamily consists of a broad range of enzymes defined by
their ability to catalyze the hydrolysis of the middle (sn-2) ester bond of substrate …

Mammalian genomes encode genes for more than 30 phospholipase A2s (PLA2s) or
related enzymes, which are subdivided into several classes including low-molecular-weight …

Phospholipase A2 (PLA2) catalyzes the hydrolysis of the sn-2 position of membrane
glycerophospholipids to liberate arachidonic acid (AA), a precursor of eicosanoids including …

Among more than 30 members of the phospholipase A 2 (PLA 2) superfamily, secreted PLA
2 (sPLA 2) enzymes represent the largest family, being Ca 2+-dependent low-molecular …

Expression of the full set of human and mouse groups I, II, V, X, and XII secreted
phospholipases A 2 (sPLA 2 s) in Escherichia coli and insect cells has provided pure …

Among the phospholipase A2 (PLA2) superfamily, which typically catalyzes the sn‐2
hydrolysis of phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 …

Secreted phospholipases A2 (sPLA2s) form a large family of structurally related enzymes
which are widespread in nature. Snake venoms are known for decades to contain a …

Group IIA secreted phospholipase A 2 (sPLA2) is known to display potent Gram-positive
bactericidal activity in vitro and in vivo. We have analyzed the bactericidal activity of the full …

Mammalian and venom secreted phospholipases A2 (sPLA2s) have been associated with a
variety of biological effects. Here we show that several sPLA2s protect human primary blood …

Mammalian secreted phospholipases A 2 (sPLA2s) comprise a group of at least eight
enzymes, including the recently identified group X sPLA2. A bacterial expression system …