The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Following introduction of the monoamine oxidase type B inhibitor selegiline for the treatment
of Parkinson's disease (PD), discovery of the action mechanism of Alzheimer's disease …

The brain constantly adapts to changes in the environment, a capability that underlies
memory and behavior. Long-term adaptations require the remodeling of neural circuits that …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Abstract 22q11. 2 deletion syndrome (22q11. 2DS) is the most common chromosomal
microdeletion disorder, estimated to result mainly from de novo non-homologous meiotic …

Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

How will we view schizophrenia in 2030? Schizophrenia today is a chronic, frequently
disabling mental disorder that affects about one per cent of the world's population. After a …

Substantial progress has been made toward understanding the genetic architecture, cellular
substrates, brain circuits and endophenotypic profiles of neuropsychiatric disorders …

Parvalbumin-expressing interneurons (PV-INs) are highly vulnerable to stressors and have
been implicated in many neuro-psychiatric diseases such as schizophrenia, Alzheimer's …