Mitochondria are major sources of reactive oxygen species (ROS) within the cell and are
especially vulnerable to oxidative stress. Oxidative damage to mitochondria results in …

The high-fat, low-carbohydrate ketogenic diet (KD) is an established treatment for drug-
resistant epilepsy with a proven efficacy. The KD is being explored for Febrile Infection …

Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …

One of the most important characteristics of the brain compared to other organs is its
elevated metabolic demand. Consequently, neurons consume high quantities of oxygen …

The roles of both neuroinflammation and oxidative stress in the pathophysiology of epilepsy
have begun to receive considerable attention in recent years. However, these concepts are …

Epilepsy is a central nervous system disorder involving spontaneous and recurring seizures
that affects 50 million individuals globally. Because approximately one-third of patients with …

Epilepsy is one of the most common symptoms of many neurological disorders. The typical
excessive, synchronous and aberrant firing of neurons originating from different cerebral …

Epilepsy is a common neurological disorder which affects patients physically and mentally
and causes a real burden for the patient, family and society both medically and …

Prevention of epilepsy is a great unmet need. Acute central nervous system (CNS) insults
such as traumatic brain injury (TBI), cerebrovascular accidents (CVA), and CNS infections …

Neuronal dysfunction due to iron accumulation in conjunction with reactive oxygen species
(ROS) could represent an important, yet underappreciated, component of the epileptogenic …