Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …

Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …

Summary The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …

MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human
leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic …

Context: Multiple endocrine neoplasia Type-1 (MEN1) in young patients is only described by
case reports. Objective: To improve the knowledge of MEN1 natural history before 21 years …

Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal-dominant disorder
characterised by the occurrence of tumours of the parathyroids, pancreas and anterior …

mSin3A is a core component of a large multiprotein corepressor complex with associated
histone deacetylase (HDAC) enzymatic activity. Physical interactions of mSin3A with many …

MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles
in development and cancer. We assessed MLL/SET proteins and found that SETD1A is …