[HTML][HTML] Multiple endocrine neoplasia type 1 (MEN1) and type 4 (MEN4)
RV Thakker - Molecular and cellular endocrinology, 2014 - Elsevier
Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …
two or more endocrine glands within a single patient. Four major forms of MEN, which are …
Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene
MC Lemos, RV Thakker - Human mutation, 2008 - Wiley Online Library
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …
DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumors (PanNETs) are a rare but clinically important form of
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …
pancreatic neoplasia. To explore the genetic basis of PanNETs, we determined the exomic …
The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis
A Yokoyama, TCP Somervaille, KS Smith… - Cell, 2005 - cell.com
Summary The Mixed-Lineage Leukemia (MLL) protein is a histone methyltransferase that is
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …
mutated in clinically and biologically distinctive subsets of acute leukemia. MLL normally …
Menin: a scaffold protein that controls gene expression and cell signaling
S Matkar, A Thiel, X Hua - Trends in biochemical sciences, 2013 - cell.com
The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
A Yokoyama, Z Wang, J Wysocka… - … and cellular biology, 2004 - Am Soc Microbiol
MLL (for mixed-lineage leukemia) is a proto-oncogene that is mutated in a variety of human
leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic …
leukemias. Its product, a homolog of Drosophila melanogaster trithorax, displays intrinsic …
MEN1 disease occurring before 21 years old: a 160-patient cohort study from the Groupe d'étude des Tumeurs Endocrines
P Goudet, A Dalac, M Le Bras… - The Journal of …, 2015 - academic.oup.com
Context: Multiple endocrine neoplasia Type-1 (MEN1) in young patients is only described by
case reports. Objective: To improve the knowledge of MEN1 natural history before 21 years …
case reports. Objective: To improve the knowledge of MEN1 natural history before 21 years …
Multiple endocrine neoplasia type 1 (MEN1)
RV Thakker - Best practice & research Clinical endocrinology & …, 2010 - Elsevier
Multiple Endocrine Neoplasia type 1 (MEN1) is an autosomal-dominant disorder
characterised by the occurrence of tumours of the parathyroids, pancreas and anterior …
characterised by the occurrence of tumours of the parathyroids, pancreas and anterior …
mSin3A corepressor regulates diverse transcriptional networks governing normal and neoplastic growth and survival
JH Dannenberg, G David, S Zhong… - Genes & …, 2005 - genesdev.cshlp.org
mSin3A is a core component of a large multiprotein corepressor complex with associated
histone deacetylase (HDAC) enzymatic activity. Physical interactions of mSin3A with many …
histone deacetylase (HDAC) enzymatic activity. Physical interactions of mSin3A with many …
A non-catalytic function of SETD1A regulates cyclin K and the DNA damage response
MLL/SET methyltransferases catalyze methylation of histone 3 lysine 4 and play critical roles
in development and cancer. We assessed MLL/SET proteins and found that SETD1A is …
in development and cancer. We assessed MLL/SET proteins and found that SETD1A is …