Diseases associated with chronic inflammation constitute a major health burden across the
world. As central instigators of the inflammatory response to infection and tissue damage …

A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

Abstract cGAS senses microbial and host-derived double-stranded DNA in cytoplasm to
trigger cellular innate immune response in a STING-dependent manner; however, it remains …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

The innate immune system serves as the first line of defense against invading pathogens;
however, dysregulated innate immune responses can induce aberrant inflammation that is …

Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from
severe multiple organ dysfunction with underlying widespread cell death. Ferroptosis and …

COVID-19 is a multisystemic disease caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2). The immunopathogenic conditions of the hyperinflammatory …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high
infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID …

The COVID-19 pandemic was caused by the recently emerged β-coronavirus SARS-CoV-2.
SARS-CoV-2 has had a catastrophic impact, resulting in nearly 7 million fatalities worldwide …