Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic …
A Yim, C Smith, AM Brown - Immunological reviews, 2022 - Wiley Online Library
Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …
Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage
V Le Douce, G Herbein, O Rohr, C Schwartz - Retrovirology, 2010 - Springer
The introduction of the highly active antiretroviral therapy (HAART) has greatly improved
survival. However, these treatments fail to definitively cure the patients and unveil the …
survival. However, these treatments fail to definitively cure the patients and unveil the …
Synaptic dysfunction in the hippocampus accompanies learning and memory deficits in human immunodeficiency virus type-1 Tat transgenic mice
S Fitting, BM Ignatowska-Jankowska, C Bull… - Biological …, 2013 - Elsevier
BACKGROUND: Human immunodeficiency virus (HIV) associated neurocognitive disorders
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …
(HAND), including memory dysfunction, continue to be a major clinical manifestation of HIV …
CNS inflammation and macrophage/microglial biology associated with HIV-1 infection
A Yadav, RG Collman - Journal of neuroimmune pharmacology, 2009 - Springer
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS)
can result in neurological dysfunction with devastating consequences in a significant …
can result in neurological dysfunction with devastating consequences in a significant …
[HTML][HTML] HIV tat and neurotoxicity
JE King, EA Eugenin, CM Buckner, JW Berman - Microbes and infection, 2006 - Elsevier
HIV tat is the transactivator of HIV-1, supporting efficient viral replication by stabilizing the
transcription of viral genes. Tat can be released from HIV-infected cells and alter several …
transcription of viral genes. Tat can be released from HIV-infected cells and alter several …
Synergistic increases in intracellular Ca2+, and the release of MCP‐1, RANTES, and IL‐6 by astrocytes treated with opiates and HIV‐1 Tat
Recent evidence suggests that injection drug users who abuse heroin are at increased risk
of CNS complications from human immunodeficiency virus (HIV) infection. Opiate drugs may …
of CNS complications from human immunodeficiency virus (HIV) infection. Opiate drugs may …
Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV‐1 Tat transgenic mice
AJ Bruce‐Keller, J Turchan‐Cholewo, EJ Smart… - Glia, 2008 - Wiley Online Library
HIV encephalitis (HIVE) is accompanied by brain inflammation, leukocyte infiltration, and
glial activation, and HIV patients who abuse opiates are more likely to develop HIVE. To …
glial activation, and HIV patients who abuse opiates are more likely to develop HIVE. To …
Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23
G Bakalkin, H Watanabe, J Jezierska… - The American Journal of …, 2010 - cell.com
Spinocerebellar ataxias (SCAs) are dominantly inherited neurodegenerative disorders
characterized by progressive cerebellar ataxia and dysarthria. We have identified missense …
characterized by progressive cerebellar ataxia and dysarthria. We have identified missense …
Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of …
The pathogenesis of human immunodeficiency virus (HIV) associated encephalopathy is
attributed to infiltration of the central nervous system (CNS) by HIV-1 infected mononuclear …
attributed to infiltration of the central nervous system (CNS) by HIV-1 infected mononuclear …
Interactive HIV-1 Tat and morphine-induced synaptodendritic injury is triggered through focal disruptions in Na+ influx, mitochondrial instability, and Ca2+ overload
Synaptodendritic injury is thought to underlie HIV-associated neurocognitive disorders and
contributes to exaggerated inflammation and cognitive impairment seen in opioid abusers …
contributes to exaggerated inflammation and cognitive impairment seen in opioid abusers …