Evidence is presented which supports the conclusion that the hormetic dose–response
model is the most common and fundamental in the biological and biomedical sciences …

The paper provides an account of how the hormetic dose response has emerged in recent
years as a serious dose-response model in toxicology and risk assessment after decades of …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

It is widely recognized that calcium is of singular importance in the viability of the myocardial
cell, nonetheless little is known concerning the precise nature of the action of calcium in …

It is well-known that micromolar to millimolar concentrations of cardiac glycosides inhibit
Na/K pump activity, however, some early reports suggested nanomolar concentrations of …

“I gave him the Infusum Digitalis stronger than usual, viz. two drams to eight ounces. Finding
himself relieved by this, he continued to take it, contrary to the directions given, after the …

by72+5/% (mean +SD,n = 21). Page 1 J. Physiol. (1977), 273, pp. 211-240 211 With 15 text-ftgure8
Printed in Great Britain THE EFFECTS OF EXTERNAL CATIONS AND OUABAIN ON THE …

METABOLIC INHIBITION induced by hypoxia or by pharmacological agents is accompanied
by pronounced changes in the electrical activity of the heart. In contractile myocardial fibers …

1 The effect of digoxin on rapid 45Ca2+ efflux from cardiac and skeletal sarcoplasmic
reticulum (SR) vesicles was investigated. Additionally the interaction of digoxin with single …

In clinical medicine, digitalis and its related glycoside analogues (eg digoxin, digitoxin) have
been used to treat heart failure and abnormal heart rhythms for at least 200 years, and very …