Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …

Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic
constituents to sustain cellular and mammalian metabolism and survival during starvation …

Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …

Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …

Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …

Infections induce complex host responses linked to antiviral defense, inflammation, and
tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may …

Simple Summary The genetic adaptability of malignant cells and their consequent
heterogeneity even within the same patient poses a great obstacle to cancer patient …

Extensive studies have shown that cancer cells have specific nutrient auxotrophy and thus
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …