Arginine signaling and cancer metabolism
Simple Summary In this review, we describe arginine's role as a signaling metabolite,
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …
epigenetic regulator and mitochondrial modulator in cancer cells, and summarize recent …
Role of tumor and host autophagy in cancer metabolism
L Poillet-Perez, E White - Genes & development, 2019 - genesdev.cshlp.org
Macroautophagy (referred to here as autophagy) degrades and recycles cytoplasmic
constituents to sustain cellular and mammalian metabolism and survival during starvation …
constituents to sustain cellular and mammalian metabolism and survival during starvation …
Immunometabolic rewiring in tumorigenesis and anti-tumor immunotherapy
X Lian, K Yang, R Li, M Li, J Zuo, B Zheng, W Wang… - Molecular Cancer, 2022 - Springer
Cellular metabolism constitutes a fundamental process in biology. During tumor initiation
and progression, each cellular component in the cancerous niche undergoes dramatic …
and progression, each cellular component in the cancerous niche undergoes dramatic …
Systemic immunometabolism: challenges and opportunities
Over the past 10 years, the field of immunometabolism made great strides to unveil the
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …
crucial role of intracellular metabolism in regulating immune cell function. Emerging insights …
[HTML][HTML] Retinopathy of prematurity: A review of pathophysiology and signaling pathways
M Fevereiro-Martins, C Marques-Neves… - survey of …, 2023 - Elsevier
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …
cause of visual impairment and childhood blindness worldwide. The disease is …
Arginase as a potential biomarker of disease progression: a molecular imaging perspective
G S. Clemente, A van Waarde, I F. Antunes… - International Journal of …, 2020 - mdpi.com
Arginase is a widely known enzyme of the urea cycle that catalyzes the hydrolysis of L-
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …
arginine to L-ornithine and urea. The action of arginase goes beyond the boundaries of …
Polymer-drug conjugates: Design principles, emerging synthetic strategies and clinical overview
Adagen, an enzyme replacement treatment for adenosine deaminase deficiency, was the
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
first protein-polymer conjugate to be approved in early 1990 s. Post this regulatory approval …
Type I interferon signaling disrupts the hepatic urea cycle and alters systemic metabolism to suppress T cell function
Infections induce complex host responses linked to antiviral defense, inflammation, and
tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may …
tissue damage and repair. We hypothesized that the liver, as a central metabolic hub, may …
Immune therapy resistance and immune escape of tumors
B Seliger, C Massa - Cancers, 2021 - mdpi.com
Simple Summary The genetic adaptability of malignant cells and their consequent
heterogeneity even within the same patient poses a great obstacle to cancer patient …
heterogeneity even within the same patient poses a great obstacle to cancer patient …
Arginine deprivation as a strategy for cancer therapy: An insight into drug design and drug combination
Y Zhang, SF Chung, SY Tam, YC Leung, X Guan - Cancer Letters, 2021 - Elsevier
Extensive studies have shown that cancer cells have specific nutrient auxotrophy and thus
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …
have much a higher demand for certain nutrients than normal cells. Amino acid deprivation …