Classification of rare missense variants as neutral or disease causing is a challenge and
has important implications for genetic counseling. A multifactorial likelihood model for …

We have performed screening in 287 breast/ovarian cancer families in Greece which has
revealed that∼ 12%(8/65) of all index patients-carriers of a deleterious mutation in BRCA1 …

Background/Aim: Numerous missense mutations have been determined in the BRCT
domain of the BRCA1 gene, affecting localization and interaction of BRCA1 with other …

The breast cancer tumor suppressor protein BRCA1 is involved in DNA repair and cell cycle
control. Mutations at the two C‐terminal tandem (BRCT) repeats of BRCA1 detected in …

Missense mutations at the BRCT domain of human BRCA1 protein have been associated
with an elevated risk for hereditary breast/ovarian cancer. They have been shown to affect …

Tandem breast cancer C-terminal (BRCT) domains, present in many DNA repair and cell
cycle checkpoint signaling proteins, are phosphoprotein binding modules. The best …

The BRCA1-associated RING domain protein 1 (BARD1) is the heterodimeric partner of
BRCA1. The BRCA1/BARD1 complex demonstrates ubiquitin ligase activity and has been …

The elongation factors (EF-Tu/EF-1α) are universal proteins, involved in protein
biosynthesis. A detailed characterization of the stability against temperature of SsEF-1α, a …

BRCTs are protein-docking modules involved in eukaryotic DNA repair. They are
characterized by low sequence homology with generally well-conserved structure …

Οι επαναλήψεις BRCT είναι δομικά πρωτεϊνικά στοιχεία με ικανότητα δέσμευσης
φωσφοπεπτιδίων που εμφανίζονται συχνά σε πρωτεΐνες που συμμετέχουν στα δίκτυα …