HIV infection, inflammation, immunosenescence, and aging
SG Deeks - Annual review of medicine, 2011 - annualreviews.org
Although antiretroviral therapy for HIV infection prevents AIDS-related complications and
prolongs life, it does not fully restore health. Long-term treated patients remain at higher than …
prolongs life, it does not fully restore health. Long-term treated patients remain at higher than …
Immunosenescence and HIV
PURPOSE OF REVIEW: The present review discusses the interplay between HIV infection
and other environmental factors (eg co-infection with CMV) in the acceleration of the aging …
and other environmental factors (eg co-infection with CMV) in the acceleration of the aging …
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
MM Lederman, L Calabrese… - Journal of Infectious …, 2011 - academic.oup.com
Background. Failure to normalize CD4+ T-cell numbers despite effective antiretroviral
therapy is an important problem in human immunodeficiency virus (HIV) infection. Methods …
therapy is an important problem in human immunodeficiency virus (HIV) infection. Methods …
Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients
L Yan, K Xu, Q Xiao, L Tuo, T Luo, S Wang… - Frontiers in …, 2023 - frontiersin.org
Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore
immune function in most people living with human immunodeficiency virus (HIV). However …
immune function in most people living with human immunodeficiency virus (HIV). However …
Immunodiscordant responses to HAART–mechanisms and consequences
M Massanella, E Negredo, B Clotet… - Expert review of clinical …, 2013 - Taylor & Francis
A relevant fraction of HIV-1-infected individuals (ranging from 15 to 30%) presenting
virologically successful highly active antiretroviral therapy fail to recover CD4 T-cell counts …
virologically successful highly active antiretroviral therapy fail to recover CD4 T-cell counts …
Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans
S Ferrando-Martínez, MC Romero-Sánchez, R Solana… - Age, 2013 - Springer
Relationship between thymic function and elderly survival has been suspected, despite the
fact that formal proof is elusive due to technical limitations of thymic function-related markers …
fact that formal proof is elusive due to technical limitations of thymic function-related markers …
Immunogenicity of a monovalent 2009 influenza A (H1N1) vaccine in an immunocompromised population: a prospective study comparing HIV-infected adults with HIV …
NF Crum-Cianflone, LE Eberly… - Clinical Infectious …, 2011 - academic.oup.com
Background. Limited data exist on the immunogenicity of the 2009 influenza A (H1N1)
vaccine among immunocompromised persons, including those with human …
vaccine among immunocompromised persons, including those with human …
Frailty, markers of immune activation and oxidative stress in HIV infected elderly
People living with HIV-1 experience an accelerated aging due to the persistent and chronic
activation of the immune system. This phenomenon conduces to immune exhaustion and …
activation of the immune system. This phenomenon conduces to immune exhaustion and …
Association between use of HMG CoA reductase inhibitors and mortality in HIV-infected patients
RD Moore, JG Bartlett, JE Gallant - PloS one, 2011 - journals.plos.org
Introduction HIV infection is a disease associated with chronic inflammation and immune
activation. Antiretroviral therapy reduces inflammation, but not to levels in comparable HIV …
activation. Antiretroviral therapy reduces inflammation, but not to levels in comparable HIV …
Thymic function as a predictor of immune recovery in chronically HIV-infected patients initiating antiretroviral therapy
R Rb-Silva, C Nobrega, C Azevedo, E Athayde… - Frontiers in …, 2019 - frontiersin.org
Poor immunological responders (PIR) are HIV-infected patients with virologic suppression
upon antiretroviral therapy (ART) but persistently low CD4+ T cell counts. Early identification …
upon antiretroviral therapy (ART) but persistently low CD4+ T cell counts. Early identification …