The biopharmaceutical market has come a long way since 1982, when the first
biopharmaceutical product, recombinant human insulin, was launched. Just over 200 …

Advancements in peptide fusion technologies to maximize the protein production has taken
a big leap to fulfill the demands of post-genomics era targeting elucidation of …

Enzymes are increasingly applied as biocatalysts for fulfilling industrial needs in a variety of
applications and there is a bursting of interest for novel therapeutic proteins. Consequently …

Bacterial systems are widely applied as production platforms for proteins of
biopharmaceutical or therapeutic interest and industrial enzymes. Among these prokaryotic …

The new generation of biological products are largely the result of genetic engineering. The
qualitative and quantitative demand for recombinant proteins is steadily increasing …

The gene encoding the 45/47 kDa glycoprotein (Rv1860) of Mycobacterium tuberculosis
was expressed in Streptomyces lividans under its own promoter and under the thiostrepton …

Bacteria are of tremendous importance in the pharma-and bio-industry as producers of a
broad range of economically interesting metabolites and proteins. Gram-positive bacteria …

Streptomyces is an interesting host for the secretory production of recombinant proteins
because of its natural ability to secrete high levels of active proteins into the culture broth …

Abstract Background In Streptomyces, understanding the switch from primary to secondary
metabolism is important for maximizing the production of secondary metabolites such as …

Recent results with respect to the secretory production of bio-active Mycobacterium
tuberculosis proteins in Streptomyces have stimulated the further exploitation of this host as …