The sympathetic nervous system and blood pressure in humans: implications for hypertension

JP Fisher, JFR Paton - Journal of human hypertension, 2012 - nature.com
A neurogenic component to primary hypertension (hypertension) is now well established.
Along with raised vasomotor tone and increased cardiac output, the chronic activation of the …

Essential hypertension: an approach to its etiology and neurogenic pathophysiology

JJ Bolívar - International journal of hypertension, 2013 - Wiley Online Library
Essential hypertension, a rise in blood pressure of undetermined cause, includes 90% of all
hypertensive cases and is a highly important public health challenge that remains, however …

[HTML][HTML] 2022 Guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension

TD Wang, CE Chiang, TH Chao, HM Cheng… - Acta Cardiologica …, 2022 - ncbi.nlm.nih.gov
Hypertension is the most important modifiable cause of cardiovascular (CV) disease and all-
cause mortality worldwide. Despite the positive correlations between blood pressure (BP) …

[HTML][HTML] HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia

S Zhang, L Hu, J Jiang, H Li, Q Wu, K Ooi… - Journal of …, 2020 - Springer
Background Microglial mediated neuroinflammation in the rostral ventrolateral medulla
(RVLM) plays roles in the etiology of stress-induced hypertension (SIH). It was reported that …

Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension

J Zubcevic, H Waki, MK Raizada, JFR Paton - Hypertension, 2011 - Am Heart Assoc
Hypertension is the single most important risk factor for cardiovascular disease and, thus,
remains a global public health challenge. Significant progress has been made during the …

Neuroinflammation and sympathetic overactivity: Mechanisms and implications in hypertension

D Haspula, MA Clark - Autonomic Neuroscience, 2018 - Elsevier
Essential hypertension is a multifactorial disorder with a strong genetic predisposition.
Although anti-hypertensive medications have drastically reduced cardiovascular diseases …

Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity

LC Vianna, EC Hart, ST Fairfax… - American Journal …, 2012 - journals.physiology.org
The sympathetic nervous system is critical for the beat-to-beat regulation of arterial blood
pressure (BP). Although studies have examined age-and sex-related effects on BP control …

Cardiac sympathetic afferent reflex and its implications for sympathetic activation in chronic heart failure and hypertension

WW Chen, XQ Xiong, Q Chen, YH Li… - Acta …, 2015 - Wiley Online Library
Persistent excessive sympathetic activation greatly contributes to the pathogenesis of
chronic heart failure (CHF) and hypertension. Cardiac sympathetic afferent reflex (CSAR) is …

Psychological stress in pathogenesis of essential hypertension

AV Ushakov, VS Ivanchenko… - Current hypertension …, 2016 - ingentaconnect.com
The article represents literature review and provides evidence for psychological stress to
play essential role in the development of arterial hypertension. The pathogenesis of …

[HTML][HTML] Targeting features of the metabolic syndrome through sympatholytic effects of SGLT2 inhibition

LY Herat, J Matthews, O Azzam, MP Schlaich… - Current Hypertension …, 2022 - Springer
Abstract Purpose of Review The moderate glucose-lowering effect of sodium glucose co-
transporter 2 (SGLT2) inhibitors is unlikely to explain SGLT2 inhibitor-mediated beneficial …