CD36, also known as the scavenger receptor B2, is a multifunctional receptor widely
expressed in various organs. CD36 plays a crucial role in the uptake of long-chain fatty …

Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have
emerged as a powerful tool for disease modeling, though their immature nature currently …

Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in
hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow …

Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere
protein-encoding genes (ie genotype-positive HCM). In an increasing number of patients …

Background: Obstructive hypertrophic cardiomyopathy (oHCM) is characterized by
unexplained left ventricular (LV) hypertrophy associated with dynamic LV outflow tract …

The sarcomere as the smallest contractile unit is prone to alterations in its functional,
structural and associated proteins. Sarcomeric dysfunction leads to heart failure or …

Hypertrophic cardiomyopathy is one of the most common inherited cardiomyopathies and a
leading cause of sudden cardiac death in young adults. Despite profound insights into the …

Hypertrophic cardiomyopathy (HCM) is characterized by phenotypic heterogeneity. We
investigated the molecular basis of the cardiac phenotype in two mouse models at …

The advent of human induced pluripotent stem cells (hiPSCs) and their capacity to be
differentiated into beating human cardiomyocytes (CMs) in vitro has revolutionized human …

Hereditary hypertrophic cardiomyopathy (HCM), due to mutations in sarcomere proteins,
occurs in more than 1/500 individuals and is the leading cause of sudden cardiac death in …