Toll-like receptor signaling and its role in cell-mediated immunity
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …
PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)
M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …
Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities
Y Luo, Y Song - International journal of molecular sciences, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides
antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities …
antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities …
The role of Toll-like receptors and neuroinflammation in Parkinson's disease
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …
Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
Toll-like receptors and the control of immunity
KA Fitzgerald, JC Kagan - Cell, 2020 - cell.com
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …
PROTAC'ing oncoproteins: targeted protein degradation for cancer therapy
Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …
durability of their effectiveness can be limited. Resistance to these therapies is often related …
TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …
immune response and its activation by bacterial endotoxin is responsible for chronic and …
Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …
immune functions with emphasis on their significance, function, regulation and expression …