Toll-like receptor signaling and its role in cell-mediated immunity

T Duan, Y Du, C Xing, HY Wang, RF Wang - Frontiers in Immunology, 2022 - frontiersin.org
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

M He, C Cao, Z Ni, Y Liu, P Song, S Hao, Y He… - … and Targeted Therapy, 2022 - nature.com
Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

A Ciesielska, M Matyjek, K Kwiatkowska - Cellular and molecular life …, 2021 - Springer
Abstract Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-
inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide …

Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities

Y Luo, Y Song - International journal of molecular sciences, 2021 - mdpi.com
Antimicrobial peptides (AMPs) are regarded as a new generation of antibiotics. Besides
antimicrobial activity, AMPs also have antibiofilm, immune-regulatory, and other activities …

The role of Toll-like receptors and neuroinflammation in Parkinson's disease

A Heidari, N Yazdanpanah, N Rezaei - Journal of Neuroinflammation, 2022 - Springer
Background Parkinson's disease (PD) is the second most prevalent neurodegenerative
disorder, characterized by motor and non-motor symptoms, significantly affecting patients' …

Kinase inhibition in autoimmunity and inflammation

AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …

Toll-like receptors and the control of immunity

KA Fitzgerald, JC Kagan - Cell, 2020 - cell.com
The study of innate immunity and its link to inflammation and host defense encompasses
diverse areas of biology, ranging from genetics and biophysics to signal transduction and …

PROTAC'ing oncoproteins: targeted protein degradation for cancer therapy

JM Kelm, DS Pandey, E Malin, H Kansou, S Arora… - Molecular Cancer, 2023 - Springer
Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …

TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis

NN Kuzmich, KV Sivak, VN Chubarev, YB Porozov… - Vaccines, 2017 - mdpi.com
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate
immune response and its activation by bacterial endotoxin is responsible for chronic and …

Toll-like receptors: significance, ligands, signaling pathways, and functions in mammals

MK Vidya, VG Kumar, V Sejian, M Bagath… - International reviews …, 2018 - Taylor & Francis
This review attempts to cover the implication of the toll-like receptors (TLRs) in controlling
immune functions with emphasis on their significance, function, regulation and expression …