Protein misfolding and aggregation in proteinopathies: causes, mechanism and cellular response
MR Ajmal - Diseases, 2023 - mdpi.com
Proteins are central to life functions. Alterations in the structure of proteins are reflected in
their function. Misfolded proteins and their aggregates present a significant risk to the cell …
their function. Misfolded proteins and their aggregates present a significant risk to the cell …
A mechanistic insight into protein-ligand interaction, folding, misfolding, aggregation and inhibition of protein aggregates: An overview
This review article summarises the possible mechanisms of the protein-ligand interaction,
folding, misfolding, aggregation and inhibition of protein aggregates. Under certain stressed …
folding, misfolding, aggregation and inhibition of protein aggregates. Under certain stressed …
Application of Fe3O4@ SiO2/MWCNT film on glassy carbon electrode for the sensitive electroanalysis of levodopa
MR Ganjali, H Salimi, S Tajik, H Beitollahi… - International Journal of …, 2017 - Elsevier
A Fe 3 O 4@ SiO 2/MWCNT (FSCNT) film was coated on a glassy carbon electrode, and
then electrochemical oxidation behavior of levodopa was considered in PBS (pH 7.0) by …
then electrochemical oxidation behavior of levodopa was considered in PBS (pH 7.0) by …
Smartphone-based differential pulse amperometry system for real-time monitoring of levodopa with carbon nanotubes and gold nanoparticles modified screen-printing …
Parkinson's disease caused by lack of dopamine in brain is a common neurodegenerative
disorder. The traditional treatment is to replenish levodopa since it could pass through blood …
disorder. The traditional treatment is to replenish levodopa since it could pass through blood …
In-situ anchoring bimetallic nanoparticles on covalent organic framework as an ultrasensitive electrochemical sensor for levodopa detection
X Sun, N Wang, Y Xie, H Chu, Y Wang, Y Wang - Talanta, 2021 - Elsevier
Covalent organic frameworks (COFs) have been studied in many fields. However, their
electrochemical properties were seldom reported. In this work, a novel high electrocatalytic …
electrochemical properties were seldom reported. In this work, a novel high electrocatalytic …
[HTML][HTML] Cold atmospheric plasma induces the curing mechanism of diabetic wounds by regulating the oxidative stress mediators iNOS and NO, the pyroptotic …
G Badr, FM El-Hossary, FEM Lasheen, NZ Negm… - Biomedicine & …, 2023 - Elsevier
It has been demonstrated that cold atmospheric plasma (CAP) accelerates the wound
healing process, however the underlying molecular pathways behind this effect remain …
healing process, however the underlying molecular pathways behind this effect remain …
Revisiting the conformational transition model for the pH dependence of BSA structure using photoluminescence, circular dichroism, and ellipsometric Raman …
LFT de Resende, FC Basilio, P Alliprandini Filho… - International Journal of …, 2024 - Elsevier
Abstract Changes in pH affect metabolic pathways, primarily by modulating enzyme
conformations, which is why a detailed analysis of pH-driven conformational transitions is …
conformations, which is why a detailed analysis of pH-driven conformational transitions is …
Protective effects of three structurally similar polyphenolic compounds against oxidative damage and their binding properties to human serum albumin
C Zhang, J Guan, J Zhang, J Yang, X Wang, X Peng - Food Chemistry, 2021 - Elsevier
Abstract Brazilin (Bra), hematoxylin (Hto) and hematein (Hte) are structurally similar
polyphenols having rich biological activities, but their antioxidant ability has not been well …
polyphenols having rich biological activities, but their antioxidant ability has not been well …
Heparin accelerates the protein aggregation via the downhill polymerization mechanism: multi-spectroscopic studies to delineate the implications on proteinopathies
Heparin is one of the members of the glycosaminoglycan (GAG) family, which has been
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …
associated with protein aggregation diseases including Alzheimer's disease, Parkinson's …
Interaction of anticancer drug clofarabine with human serum albumin and human α-1 acid glycoprotein. Spectroscopic and molecular docking approach
The binding interaction between clofarabine, an important anticancer drug and two
important carrier proteins found abundantly in human plasma, Human Serum Albumin (HSA) …
important carrier proteins found abundantly in human plasma, Human Serum Albumin (HSA) …