Prone positioning was first proposed in the 1970s as a method to improve gas exchange in
ARDS. Subsequent observations of dramatic improvement in oxygenation with simple …

ARDS is severe form of respiratory failure with significant impact on the morbidity and
mortality of critical care patients. Epidemiological data are crucial for evaluating the efficacy …

Background Current management practices and outcomes in weaning from invasive
mechanical ventilation are poorly understood. We aimed to describe the epidemiology …

Rationale: The weaning process concerns all patients receiving mechanical ventilation. A
previous classification into simple, prolonged, and difficult weaning ignored weaning failure …

Introduction While prone positioning (PP) has been shown to improve patient survival in
moderate to severe acute respiratory distress syndrome (ARDS) patients, the rate of …

Purpose To improve the outcome of the acute respiratory distress syndrome (ARDS), one
needs to identify potentially modifiable factors associated with mortality. Methods The large …

Context Lung-protective mechanical ventilation with the use of lower tidal volumes has been
found to improve outcomes of patients with acute respiratory distress syndrome (ARDS). It …

Rationale: Baseline characteristics and management have changed over time in patients
requiring mechanical ventilation; however, the impact of these changes on patient outcomes …

Background In patients undergoing mechanical ventilation for the acute respiratory distress
syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease …

Importance Although most critically ill patients receive invasive mechanical ventilation (IMV),
few studies have characterized how IMV is discontinued in practice. Objective To describe …