Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy

Z Liu, X Lu, V Villette, Y Gou, KL Colbert, S Lai, S Guan… - Cell, 2022 - cell.com
Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics
with cell-type specificity. However, current indicators enable a narrow range of applications …

Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types

M Kannan, G Vasan, S Haziza, C Huang… - Science, 2022 - science.org
Genetically encoded fluorescent voltage indicators are ideally suited to reveal the
millisecond-scale interactions among and between targeted cell populations. However …

FIOLA: an accelerated pipeline for fluorescence imaging online analysis

C Cai, C Dong, J Friedrich, M Rozsa… - Nature …, 2023 - nature.com
Optical microscopy methods such as calcium and voltage imaging enable fast activity
readout of large neuronal populations using light. However, the lack of corresponding …

Sensitivity optimization of a rhodopsin-based fluorescent voltage indicator

AS Abdelfattah, J Zheng, A Singh, YC Huang, D Reep… - Neuron, 2023 - cell.com
The ability to optically image cellular transmembrane voltages at millisecond-timescale
resolutions can offer unprecedented insight into the function of living brains in behaving …

Widefield imaging of rapid pan-cortical voltage dynamics with an indicator evolved for one-photon microscopy

X Lu, Y Wang, Z Liu, Y Gou, D Jaeger… - Nature …, 2023 - nature.com
Widefield imaging with genetically encoded voltage indicators (GEVIs) is a promising
approach for understanding the role of large cortical networks in the neural coding of …

Statistically unbiased prediction enables accurate denoising of voltage imaging data

M Eom, S Han, P Park, G Kim, ES Cho, J Sim, KH Lee… - Nature …, 2023 - nature.com
Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal
information in imaging data), a self-supervised learning method for removing Poisson …

[HTML][HTML] Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish

UL Böhm, Y Kimura, T Kawashima, MB Ahrens… - Neuron, 2022 - cell.com
Motor systems must continuously adapt their output to maintain a desired trajectory. While
the spinal circuits underlying rhythmic locomotion are well described, little is known about …

Imaging voltage with microbial rhodopsins

XM Zhang, T Yokoyama, M Sakamoto - Frontiers in Molecular …, 2021 - frontiersin.org
Membrane potential is the critical parameter that reflects the excitability of a neuron, and it is
usually measured by electrophysiological recordings with electrodes. However, this is an …

Scanless two-photon voltage imaging

RR Sims, I Bendifallah, C Grimm… - Nature …, 2024 - nature.com
Two-photon voltage imaging has long been heralded as a transformative approach capable
of answering many long-standing questions in modern neuroscience. However, exploiting …

All-optical electrophysiology in behaving animals

Y Adam - Journal of Neuroscience Methods, 2021 - Elsevier
Technology for simultaneous control and readout of the membrane potential of multiple
neurons in behaving animals at high spatio-temporal resolution will have a high impact on …