Amide bond forming reactions are critical for both polypeptide synthesis and medicinal
chemistry. Most current approaches for amidation employ stoichiometric activating agents …

The amide bond N− C activation represents a powerful strategy in organic synthesis to
functionalize the historically inert amide linkage. This personal account highlights recent …

Cross-coupling reactions, which were discovered almost 50 years ago, are widely used in
both industry and academia. Even though cross-coupling reactions now represent mature …

Metal-catalyzed cross-couplings represent one of the most important reaction platforms in
modern synthetic chemistry (Figure 1 A). 1 Although the field enjoys a rich history, there …

The amide bond is one of the most fundamental functional groups in chemistry and biology
and plays a central role in numerous processes harnessed to streamline the synthesis of key …

The synthesis of amides is a key technology for the preparation of fine and bulk chemicals in
industry, as well as the manufacture of a plethora of daily life products. Furthermore, it …

The direct mechanochemical amidation of esters by ball milling is described. The
operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu …

Rhodium‐catalyzed C7‐selective decarbonylative arylation, olefination, and methylation of
indoles with carboxylic acids or anhydrides by C− H and C− C bond activation have been …

Amides are one of the most important organic compounds that are widely applied in
medicine, biochemistry, and materials science. To find an efficient synthetic method of …

Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …