Currently, enhancement of cholinergic neurotransmission via cholinesterase inhibitors
represents the main available approach to treat cognitive and behavioural symptoms of the …

Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Objective Postural instability and gait difficulties (PIGDs) represent debilitating disturbances
in Parkinson's disease (PD). Past acetylcholinesterase positron emission tomography (PET) …

Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …

Alzheimer's disease neurodegeneration is thought to spread across anatomically and
functionally connected brain regions. However, the precise sequence of spread remains …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Recent models of Alzheimer's Disease (AD) suggest that neuropathological changes of the
medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the …

Emerging research has re-emphasized the role of the cortical cholinergic system in the
symptomology and progression of Alzheimer's disease (AD). Basal forebrain (BF) …

Background Rapid-eye movement (REM) sleep highly depends on the activity of cholinergic
basal forebrain (BF) neurons and is reduced in Alzheimer's disease. Here, we investigated …