Many recent advances have emerged in the telomere and telomerase fields. This Timeline
article highlights the key advances that have expanded our views on the mechanistic …

The finding that transcription occurs at chromosome ends has opened new fields of study on
the roles of telomeric transcripts in chromosome end maintenance and genome stability …

Although elongation of telomeres is thought to be the prime function of reactivated
telomerase in cancers, this activity alone does not account for all of the properties that …

Shelterin and nucleosomes are the key players that organize mammalian chromosome ends
into the protective telomere caps. However, how they interact with each other at telomeres …

Telomerase is expressed in early human development and then becomes silenced in most
normal tissues. Because~ 90% of primary human tumors express telomerase and generally …

In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful
replication of genetic materials and protection against DNA damage signals, to ensure …

Telomeres (the TTAGGG repetitive DNA at the ends of linear chromosomes) are part of the
3D spatial organization of the nuclear genome. Long-range 3D chromatin interactions also …

Break-induced replication (BIR) repairs one-ended double-strand DNA breaks through
invasion into a homologous template followed by DNA synthesis. Different from S-phase …

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is
associated with cellular ageing. Telomere protection involves the insertion of the 3 …

Tandem DNA repeats derived from the ancestral (TTAGGG) n run were first detected at
chromosome ends of the majority of living organisms, hence the name telomeric DNA …