Bee venom: Overview of main compounds and bioactivities for therapeutic interests

R Wehbe, J Frangieh, M Rima, D El Obeid, JM Sabatier… - Molecules, 2019 - mdpi.com
Apitherapy is an alternate therapy that relies on the usage of honeybee products, most
importantly bee venom for the treatment of many human diseases. The venom can be …

Antimicrobial peptides: mechanism of action, activity and clinical potential

QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …

Applications and evolution of melittin, the quintessential membrane active peptide

S Guha, RP Ferrie, J Ghimire, CR Ventura, E Wu… - Biochemical …, 2021 - Elsevier
Melittin, the main venom component of the European Honeybee, is a cationic linear peptide-
amide of 26 amino acid residues with the sequence: GIGAVLKVLTTGLPALISWIKRKRQQ …

Bee venom: From venom to drug

A Khalil, BH Elesawy, TM Ali, OM Ahmed - Molecules, 2021 - mdpi.com
Insects of the order Hymenoptera have a defensive substance that contains many
biologically active compounds. Specifically, venom from honeybees (Apis mellifera) contains …

Biosynthesis, bioactivity, biotoxicity and applications of antimicrobial peptides for human health

D Wei, X Zhang - Biosafety and Health, 2022 - mednexus.org
Antimicrobial peptides (AMPs) are the natural antibiotics recognized for their broad-
spectrum resistance to bacteria, fungi, viruses and parasites, and influencing the host …

Bee venom—a potential complementary medicine candidate for SARS-CoV-2 infections

KI Kasozi, G Niedbała, M Alqarni, G Zirintunda… - Frontiers in public …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by severe
cytokine storm syndrome following inflammation. SARS-CoV-2 directly interacts with …

Mechanistic understanding from molecular dynamics in pharmaceutical research 2: lipid membrane in drug design

T Róg, M Girych, A Bunker - Pharmaceuticals, 2021 - mdpi.com
We review the use of molecular dynamics (MD) simulation as a drug design tool in the
context of the role that the lipid membrane can play in drug action, ie, the interaction …

Ferritin nanocages for protein delivery to tumor cells

F Palombarini, E Di Fabio, A Boffi, A Macone… - Molecules, 2020 - mdpi.com
The delivery of therapeutic proteins is one of the greatest challenges in the treatment of
human diseases. In this frame, ferritins occupy a very special place. Thanks to their hollow …

Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption

T Rončević, M Gerdol, M Mardirossian, M Maleš… - Acta biomaterialia, 2022 - Elsevier
An infecting and propagating parasite relies on its innate defense system to evade the host's
immune response and to survive challenges from commensal bacteria. More so for the …

Antimicrobial proteins: structure, molecular action, and therapeutic potential

M Hassan, TW Flanagan, N Kharouf, C Bertsch… - Pharmaceutics, 2022 - mdpi.com
Second-and third-line treatments of patients with antibiotic-resistant infections can have
serious side effects, such as organ failure with prolonged care and recovery. As clinical …