Applications of single-cell RNA sequencing in drug discovery and development
B Van de Sande, JS Lee, E Mutasa-Gottgens… - Nature Reviews Drug …, 2023 - nature.com
Single-cell technologies, particularly single-cell RNA sequencing (scRNA-seq) methods,
together with associated computational tools and the growing availability of public data …
together with associated computational tools and the growing availability of public data …
Immune cell interactions in tuberculosis
JAL Flynn, J Chan - Cell, 2022 - cell.com
Despite having been identified as the organism that causes tuberculosis in 1882,
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
Mycobacterium tuberculosis has managed to still evade our understanding of the protective …
T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection
Antigen-specific, MHC-restricted αβ T cells are necessary for protective immunity against
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
Mycobacterium tuberculosis, but the ability to broadly study these responses has been …
CD8+ lymphocytes are critical for early control of tuberculosis in macaques
CG Winchell, SK Nyquist, MC Chao, P Maiello… - Journal of Experimental …, 2023 - rupress.org
The functional role of CD8+ lymphocytes in tuberculosis remains poorly understood. We
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …
depleted innate and/or adaptive CD8+ lymphocytes in macaques and showed that loss of all …
Airway T cells are a correlate of iv Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
Summary Bacille Calmette-Guerin (BCG), the only approved Mycobacterium tuberculosis
(Mtb) vaccine, provides limited durable protection when administered intradermally …
(Mtb) vaccine, provides limited durable protection when administered intradermally …
Intravenous Bacille Calmette–Guérin vaccination protects simian immunodeficiency virus-infected macaques from tuberculosis
EC Larson, AL Ellis-Connell, MA Rodgers… - Nature …, 2023 - nature.com
Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most common cause of
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille …
death in people living with human immunodeficiency virus (HIV). Intra-dermal Bacille …
A half-century of research on tuberculosis: Successes and challenges
BR Bloom - Journal of Experimental Medicine, 2023 - rupress.org
Great progress has been made over the past half-century, but TB remains a formidable
global health problem, particularly in low-and middle-income countries. Understanding the …
global health problem, particularly in low-and middle-income countries. Understanding the …
Key advances in vaccine development for tuberculosis—Success and challenges
Breakthrough findings in the clinical and preclinical development of tuberculosis (TB)
vaccines have galvanized the field and suggest, for the first time since the development of …
vaccines have galvanized the field and suggest, for the first time since the development of …
The dense-core plaques of Alzheimer's disease are granulomas
Dense-core plaques, whose centers contain highly polymerized and compacted aggregates
of amyloid β peptides, are one of the two defining histopathological features of Alzheimer's …
of amyloid β peptides, are one of the two defining histopathological features of Alzheimer's …
Initial immune response after exposure to Mycobacterium tuberculosis or to SARS-COV-2: similarities and differences
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) and Coronavirus disease-
2019 (COVID-19), whose etiologic agent is severe acute respiratory syndrome coronavirus …
2019 (COVID-19), whose etiologic agent is severe acute respiratory syndrome coronavirus …