Objective: To develop a clinical practice guideline for red blood cell transfusion in adult
trauma and critical care. Design: Meetings, teleconferences and electronic-based …

BACKGROUND: A minority of patients having cardiac procedures (15% to 20%) consume
more than 80% of the blood products transfused at operation. Blood must be viewed as a …

Context Hemoglobin-based blood substitutes (HBBSs) are infusible oxygen-carrying liquids
that have long shelf lives, have no need for refrigeration or cross-matching, and are ideal for …

Background We have previously shown that blood transfusion in the first 24 hours is an
independent predictor of mortality, intensive care unit (ICU) admission, and increased ICU …

The complications associated with acquiring and storing whole blood for transfusions have
launched substantial efforts to develop a blood substitute. The history of these efforts …

Background Normothermic machine perfusion of the liver (NMP-L) is a novel technique that
preserves liver grafts under near-physiological conditions while maintaining their normal …

Several aspects of the management of an orthopaedic surgical patient are not directly
related to the surgical technique but are nevertheless essential for a successful outcome …

SEMISYNTHETIC or synthetic preparations of hemoglobin, now termed hemoglobin-based
oxygen carriers (HBOCs), have been in development as an alternative to erythrocytes for …

Two distinct approaches are being explored in red blood cell substitute (RCS) development:
hemoglobin‐based oxygen carriers (HBOCs) and perfluorocarbon‐based oxygen carriers …

Background: The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely
reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery …