The PE/PPE multigene family codes for approximately 10% of the Mycobacterium
tuberculosis proteome and is encoded by 176 open reading frames. These proteins …

India already has earned the dubious distinction of being one of the countries with the
highest incidence of tuberculosis (TB). The conventional control measures have had little …

Abstract Background The PE and PPE multigene families of Mycobacterium tuberculosis
comprise about 10% of the coding potential of the genome. The function of the proteins …

Vaccines are the pharmaceutical products that offer the best cost‐benefit ratio in the pre‐-
vention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine …

Abstract Background The genome of Mycobacterium tuberculosis harbors four copies of a
cluster of genes termed mce operons. Despite extensive research that has demonstrated the …

The cell wall of mycobacteria contains an unusual outer membrane of extremely low
permeability. While Escherichia coli uses more than 60 proteins to functionalize its outer …

We have previously shown that≈ 5% of the genes encoded by the genome of
Mycobacterium tuberculosis are specifically required for the growth or survival of this …

Mycobacteria have a distinctive glycolipid-rich outer membrane, the mycomembrane, which
is a critical target for tuberculosis drug development. However, proteins that associate with …

Iron is essential for replication of Mycobacterium tuberculosis, but iron is efficiently
sequestered in the human host during infection. Heme constitutes the largest iron reservoir …

This study investigates an efficient and accurate computational method for predicating
mycobacterial membrane protein. Mycobacterium is a pathogenic bacterium which is the …